Synthesis and photo-activity of peptide nucleic acids containing an azobenzene unit
نویسندگان
چکیده
منابع مشابه
Facile synthesis of peptide nucleic acids and peptide nucleic acid-peptide conjugates on an automated peptide synthesizer.
Peptide nucleic acids (PNAs) are DNA mimics with a neutral peptide backbone instead of the negatively charged sugar phosphates. PNAs exhibit several attractive features such as high chemical and thermal stability, resistance to enzymatic degradation, and stable binding to their RNA or DNA targets in a sequence-specific manner. Therefore, they are widely used in molecular diagnosis of antisense-...
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Peptide nucleic acids (PNAs) are structural mimics of nucleic acids that form stable hybrids with DNA and RNA. In addition, PNAs can invade double-stranded DNA. Due to these characteristics, PNAs are widely used as biochemical tools, for example, in antisense/antigene therapy. Interstrand crosslink formation in nucleic acids is one of the strategies for preparing a stable duplex by covalent bon...
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Photo- and thermal-responsive polymers containing azobenzene units in the main chain have been utilized as removable dispersants for single-walled carbon nanotubes (SWNTs) in organic solvents. Intermolecular interactions between SWNTs and the polymers are reversibly controllable by tuning the trans-cis composition.
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SYNTHESIS 2006, No. 4, pp 0645–0653xx.xx.2006 Advanced online publication: 25.01.2006 DOI: 10.1055/s-2006-926313; Art ID: M05505SS © Georg Thieme Verlag Stuttgart · New York Abstract: Starting from glycidol, the synthesis of dimethoxytritylated glycol nucleoside phosphoramidites of adenine (A), thymine (T), uracil (U), guanine (G), and cytosine (C) is reported. These phosphoramidites are the bu...
متن کاملUnusual, photo-induced self-assembly of azobenzene-containing amphiphiles.
Stimuli-responsive self-assembly is playing an increasingly important role in emerging applications, ranging from smart materials to biosensors. However, obtaining essential information for further development, such as molecular arrangement and interaction, is still experimentally challenging. A molecular-level understanding of the stimuli-responsive self-assembly is needed. Azobenzene-containi...
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ژورنال
عنوان ژورنال: Science Bulletin
سال: 2009
ISSN: 2095-9273,2095-9281
DOI: 10.1007/s11434-009-0554-z